Электронная книга: Hugo Kubinyi «Thermodynamics and Kinetics of Drug Binding»
|
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors. Издательство: "John Wiley&Sons Limited"
ISBN: 9783527673049 электронная книга Купить за 14671.88 руб и скачать на Litres |
Другие книги автора:
| Книга | Описание | Год | Цена | Тип книги |
|---|---|---|---|---|
| Combinatorial Chemistry. A Practical Approach | As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling | Barrier, reservoir, target site– those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability | The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Virtual Screening. Principles, Challenges, and Practical Guidelines | Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Molecular Descriptors for Chemoinformatics. Volume I: Alphabetical Listing / Volume II: Appendices, References | The number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly surveyed, resulting in hundreds of new… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Prodrugs and Targeted Delivery. Towards Better ADME Properties | This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Aspartic Acid Proteases as Therapeutic Targets | In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Chemokine Receptors as Drug Targets | Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Pharmacokinetics and Metabolism in Drug Design | In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Microwaves in Organic and Medicinal Chemistry | Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Protein-Protein Interactions in Drug Discovery | Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Bioisosteres in Medicinal Chemistry | Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Phosphodiesterases and Their Inhibitors | Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Antiviral Drug Strategies | By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Protein-Ligand Interactions | Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга |
См. также в других словарях:
Partition coefficient — In chemistry and the pharmaceutical sciences, a partition (P) or distribution coefficient (D) is the ratio of concentrations of a compound in the two phases of a mixture of two immiscible solvents at equilibrium.[1] The terms gas/liquid partition … Wikipedia
List of important publications in chemistry — FoundationsThe Sceptical Chymist* Robert Boyle 1661Description: Boyle, in the form of a dialogue, argued that chemical theories should be firmly grounded in experiment before their acceptance, and for the foundation of Chemistry as a science… … Wikipedia
Enzyme — Biocatalyst redirects here. For the use of natural catalysts in organic chemistry, see Biocatalysis. Human glyoxalase I. Two zinc ions that are needed for the enzyme to catalyze its reaction are shown as purp … Wikipedia
Folding@home — Original author(s) Vijay Pande Developer(s) Stanford University / Pande lab Initial release 2000 10 01 … Wikipedia
Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… … Wikipedia
Vijay Pande — Vijay S. Pande is currently an Associate Professor in the Chemistry Department at Stanford University. Pande’s current research centers on the development and application of novel grid computing simulation techniques to address problems in… … Wikipedia
