Электронная книга: Hugo Kubinyi «Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling»

Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling

Barrier, reservoir, target site– those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors'long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Издательство: "John Wiley&Sons Limited"

ISBN: 9783527616497

электронная книга

Купить за 11582.49 руб и скачать на Litres

Другие книги автора:

КнигаОписаниеГодЦенаТип книги
Combinatorial Chemistry. A Practical ApproachAs we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and BioavailabilityThe gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit… — John Wiley&Sons Limited, электронная книга Подробнее...21929.8электронная книга
Virtual Screening. Principles, Challenges, and Practical GuidelinesDrug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional… — John Wiley&Sons Limited, электронная книга Подробнее...16756.14электронная книга
Molecular Descriptors for Chemoinformatics. Volume I: Alphabetical Listing / Volume II: Appendices, ReferencesThe number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly surveyed, resulting in hundreds of new… — John Wiley&Sons Limited, электронная книга Подробнее...40924.78электронная книга
Prodrugs and Targeted Delivery. Towards Better ADME PropertiesThis topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Aspartic Acid Proteases as Therapeutic TargetsIn this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of… — John Wiley&Sons Limited, электронная книга Подробнее...17915.12электронная книга
Chemokine Receptors as Drug TargetsChemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has… — John Wiley&Sons Limited, электронная книга Подробнее...15983.98электронная книга
Pharmacokinetics and Metabolism in Drug DesignIn this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the… — John Wiley&Sons Limited, электронная книга Подробнее...11968.57электронная книга
Microwaves in Organic and Medicinal ChemistryTailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with… — John Wiley&Sons Limited, электронная книга Подробнее...18918.79электронная книга
Protein-Protein Interactions in Drug DiscoveryTreating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Bioisosteres in Medicinal ChemistryWritten with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles… — John Wiley&Sons Limited, электронная книга Подробнее...14285.06электронная книга
Phosphodiesterases and Their InhibitorsWritten by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Antiviral Drug StrategiesBy focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel… — John Wiley&Sons Limited, электронная книга Подробнее...15983.98электронная книга
Protein-Ligand InteractionsInnovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic… — John Wiley&Sons Limited, электронная книга Подробнее...15134.89электронная книга
Reactive Drug MetabolitesClosing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first… — John Wiley&Sons Limited, электронная книга Подробнее...15057.96электронная книга

Look at other dictionaries:

  • Life Sciences — ▪ 2009 Introduction Zoology       In 2008 several zoological studies provided new insights into how species life history traits (such as the timing of reproduction or the length of life of adult individuals) are derived in part as responses to… …   Universalium

  • Nobel Prizes — ▪ 2009 Introduction Prize for Peace       The 2008 Nobel Prize for Peace was awarded to Martti Ahtisaari, former president (1994–2000) of Finland, for his work over more than 30 years in settling international disputes, many involving ethnic,… …   Universalium

  • Список награждённых Национальной медалью науки США — Джошуа Ледерберг (справа) получает Национальную медаль науки из рук Президента США Джорджа Буша старшего Список …   Википедия

  • X-ray crystallography — can locate every atom in a zeolite, an aluminosilicate with many important applications, such as water purification. X ray crystallography is a method of determining the arrangement of atoms within a crystal, in which a beam of X rays strikes a… …   Wikipedia

  • Micellar liquid chromatography — Acronym MLC Classification Chromatography Other techniques Related High performance liquid chromatography Aqueous Normal Phase Chromatography Size exclusion chromatography Ion exchange chromatography Micellar liquid chromatography (MLC) is a form …   Wikipedia

  • Copper in health — Normal absorption and distribution of copper. Cu = copper, CP = ceruloplasmin, green = ATP7B carrying copper. Copper is an essential trace element that is vital to the health of all living things (humans, plants, animals, and microorganisms). In… …   Wikipedia

  • Amino acid — This article is about the class of chemicals. For the structures and properties of the standard proteinogenic amino acids, see Proteinogenic amino acid. The generic structure of an alpha amino acid in its unionized form …   Wikipedia

  • Enzyme — Biocatalyst redirects here. For the use of natural catalysts in organic chemistry, see Biocatalysis. Human glyoxalase I. Two zinc ions that are needed for the enzyme to catalyze its reaction are shown as purp …   Wikipedia

  • Plant defense against herbivory — Poison ivy produces urushiol to protect the plant from herbivores. In humans this chemical produces an allergic skin rash, known as urushiol induced contact dermatitis …   Wikipedia

  • plant disease — ▪ plant pathology Introduction       an impairment of the normal state of a plant that interrupts or modifies its vital functions.       All species of plants, wild and cultivated alike, are subject to disease. Although each species is… …   Universalium

  • Methamphetamine — Meth and Tik redirect here. For other uses, see Meth (disambiguation) and Tik (disambiguation). This article is about the psychostimulant drug, methamphetamine, in both racemic and dextrorotatory forms. For the CNS inactive OTC nasal decongestant …   Wikipedia