Электронная книга: Hugo Kubinyi «Phosphodiesterases and Their Inhibitors»

Phosphodiesterases and Their Inhibitors

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.

Издательство: "John Wiley&Sons Limited"

ISBN: 9783527682355

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Look at other dictionaries:

  • PDE1 — (phosphodiesterase1) is a phosphodiesterase enzyme also known as calcium and calmodulin dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1 PDE11). PDE1 has three subtypes, PDE1A, PDE1B and PDE1C which divide… …   Wikipedia

  • Phosphodiesterase 2 — The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families (PDE1 – PDE11). The different PDEs of the same family are functionally related despite… …   Wikipedia

  • PDE2 — The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families (PDE1 – PDE11). The different PDEs of the same family are functionally related despite… …   Wikipedia

  • Phosphodiesterase — A phosphodiesterase is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However,… …   Wikipedia

  • PDE3 — phosphodiesterase 3A, cGMP inhibited Identifiers Symbol PDE3A Entrez 5139 HUGO …   Wikipedia

  • Antidepressant — Fluoxetine (Prozac), an SSRI The chemical structure of …   Wikipedia

  • PDE5 inhibitor — Sildenafil (Viagra), the prototypical PDE5 inhibitor A phosphodiesterase type 5 inhibitor, often shortened to PDE5 inhibitor, is a drug used to block the degradative action of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells… …   Wikipedia

  • Erectile dysfunction — Impotent redirects here. For the classification of poverty, see impotent poor. Erectile dysfunction Classification and external resources ICD 10 F52.2, N48.4 …   Wikipedia

  • Cyclic guanosine monophosphate — IUPAC name 2 amino 9 [(1S,6R,8R,9R) 3,9 dihydroxy 3 oxo 2,4,7 trioxa 3λ5 phosphabicyclo[4 …   Wikipedia

  • Adenosine receptor — The adenosine receptors (or P1 receptors[1]) are a class of purinergic receptors, G protein coupled receptors with adenosine as endogenous ligand.[2] Contents 1 Pharmacology …   Wikipedia

  • Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… …   Wikipedia