Электронная книга: Hugo Kubinyi «Data Mining in Drug Discovery»
|
Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non-commercial, while the next section looks at the role and value of data mining in drug discovery. The third part compares the most common applications and strategies for polypharmacology, where data mining can substantially enhance the research effort. The final section of the book is devoted to systems biology approaches for compound testing. Throughout the book, industrial and academic drug discovery strategies are addressed, with contributors coming from both areas, enabling an informed decision on when and which data mining tools to use for one's own drug discovery project. Издательство: "John Wiley&Sons Limited"
ISBN: 9783527656011 электронная книга Купить за 15134.89 руб и скачать на Litres |
Другие книги автора:
| Книга | Описание | Год | Цена | Тип книги |
|---|---|---|---|---|
| Combinatorial Chemistry. A Practical Approach | As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling | Barrier, reservoir, target site– those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability | The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Virtual Screening. Principles, Challenges, and Practical Guidelines | Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Molecular Descriptors for Chemoinformatics. Volume I: Alphabetical Listing / Volume II: Appendices, References | The number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly surveyed, resulting in hundreds of new… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Prodrugs and Targeted Delivery. Towards Better ADME Properties | This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Aspartic Acid Proteases as Therapeutic Targets | In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Chemokine Receptors as Drug Targets | Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Pharmacokinetics and Metabolism in Drug Design | In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Microwaves in Organic and Medicinal Chemistry | Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Protein-Protein Interactions in Drug Discovery | Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Bioisosteres in Medicinal Chemistry | Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Phosphodiesterases and Their Inhibitors | Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Antiviral Drug Strategies | By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга | ||
| Protein-Ligand Interactions | Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга |
См. также в других словарях:
Data mining — Not to be confused with analytics, information extraction, or data analysis. Data mining (the analysis step of the knowledge discovery in databases process,[1] or KDD), a relatively young and interdisciplinary field of computer science[2][3] is… … Wikipedia
Cross Industry Standard Process for Data Mining — CRISP DM stands for Cross Industry Standard Process for Data Mining[1]. It is a data mining process model that describes commonly used approaches that expert data miners use to tackle problems. Polls conducted in 2002, 2004, and 2007 show that it … Wikipedia
Discovery Net — is one of the earliest examples of a scientific workflow system allowing users to coordinate the execution of remote services based on Web service and Grid Services (OGSA and Open Grid Services Architecture) standards. The system was designed and … Wikipedia
Drug design — Not to be confused with Designer drug. Drug design, also sometimes referred to as rational drug design or structure based drug design, is the inventive process of finding new medications based on the knowledge of the biological target.[1] The… … Wikipedia
Molecule mining — This page describes mining for molecules. Since molecules may be represented by molecular graphs this is strongly related to graph mining and structured data mining. The main problem is how to represent molecules while discriminating the data… … Wikipedia
Association rule learning — In data mining, association rule learning is a popular and well researched method for discovering interesting relations between variables in large databases. Piatetsky Shapiro[1] describes analyzing and presenting strong rules discovered in… … Wikipedia
