Электронная книга: Hugo Kubinyi «Animal Models for Human Cancer. Discovery and Development of Novel Therapeutics»

Animal Models for Human Cancer. Discovery and Development of Novel Therapeutics

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Издательство: "John Wiley&Sons Limited"

ISBN: 9783527695911

электронная книга

Купить за 11212.52 руб и скачать на Litres

Другие книги автора:

КнигаОписаниеГодЦенаТип книги
Combinatorial Chemistry. A Practical ApproachAs we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Drug-Membrane Interactions. Analysis, Drug Distribution, ModelingBarrier, reservoir, target site– those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid… — John Wiley&Sons Limited, электронная книга Подробнее...11582.49электронная книга
Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and BioavailabilityThe gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit… — John Wiley&Sons Limited, электронная книга Подробнее...21929.8электронная книга
Virtual Screening. Principles, Challenges, and Practical GuidelinesDrug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional… — John Wiley&Sons Limited, электронная книга Подробнее...16756.14электронная книга
Molecular Descriptors for Chemoinformatics. Volume I: Alphabetical Listing / Volume II: Appendices, ReferencesThe number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly surveyed, resulting in hundreds of new… — John Wiley&Sons Limited, электронная книга Подробнее...40924.78электронная книга
Prodrugs and Targeted Delivery. Towards Better ADME PropertiesThis topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Aspartic Acid Proteases as Therapeutic TargetsIn this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of… — John Wiley&Sons Limited, электронная книга Подробнее...17915.12электронная книга
Chemokine Receptors as Drug TargetsChemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has… — John Wiley&Sons Limited, электронная книга Подробнее...15983.98электронная книга
Pharmacokinetics and Metabolism in Drug DesignIn this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the… — John Wiley&Sons Limited, электронная книга Подробнее...11968.57электронная книга
Microwaves in Organic and Medicinal ChemistryTailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with… — John Wiley&Sons Limited, электронная книга Подробнее...18918.79электронная книга
Protein-Protein Interactions in Drug DiscoveryTreating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Bioisosteres in Medicinal ChemistryWritten with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles… — John Wiley&Sons Limited, электронная книга Подробнее...14285.06электронная книга
Phosphodiesterases and Their InhibitorsWritten by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE… — John Wiley&Sons Limited, электронная книга Подробнее...16215.48электронная книга
Antiviral Drug StrategiesBy focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel… — John Wiley&Sons Limited, электронная книга Подробнее...15983.98электронная книга
Protein-Ligand InteractionsInnovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic… — John Wiley&Sons Limited, электронная книга Подробнее...15134.89электронная книга

См. также в других словарях:

  • Animal model — An animal model is a living, non human animal used during the research and investigation of human disease, for the purpose of better understanding the disease without the added risk of causing harm to an actual human being during the process. The …   Wikipedia

  • Drug discovery — In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed. In the past most drugs have been discovered either by identifying the active ingredient from traditional… …   Wikipedia

  • Timeline of Islamic science and engineering — This timeline of Islamic science and engineering covers the general development of science and technology in the Islamic world during the Islamic Golden Age, usually dated from the 7th to 16th centuries.From the 17th century onwards, the advances …   Wikipedia

  • Nobel Prizes — ▪ 2009 Introduction Prize for Peace       The 2008 Nobel Prize for Peace was awarded to Martti Ahtisaari, former president (1994–2000) of Finland, for his work over more than 30 years in settling international disputes, many involving ethnic,… …   Universalium

  • Natural scientific research in Canada — This article outlines the history of natural scientific research in Canada, including mathematics, physics, astronomy, space science, geology, oceanography, chemistry, biology, medical research and psychology. The social sciences are not treated… …   Wikipedia

  • pharmaceutical industry — Producers of pharmaceuticals, substances used in the diagnosis, treatment, and prevention of disease and the modification of organic functions. The earliest records of medicinal plants and minerals are those of the ancient Chinese, Hindu, and… …   Universalium

Поделиться ссылкой на выделенное

Прямая ссылка:
Нажмите правой клавишей мыши и выберите «Копировать ссылку»