Электронная книга: Li Di «Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs»

Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant– and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug deliverystrategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamicsrelationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Издательство: "John Wiley&Sons Limited"

ISBN: 9781118788547

электронная книга

Купить за 11968.57 руб и скачать на Litres

Li Di

Li Di,
 
Li Ti, chinesischer Maler, * Heyang (Provinz Henan) um 1100, ✝ Hangzhou um 1197; seine Blumen- und Tierbilder zeigen bei sparsamer Kompositionsweise lyrischen Stimmungsgehalt.
 
Werke: Vogel auf verschneitem Baum (1187; Schanghai, Museum für Kunst und Geschichte); Roter und weißer Hibiscus (1197; Tokio, Nationalmuseum); Büffel und Hirt auf dem Heimweg im Schnee (Nara, Sammlung Yamato Bunkakan).

Источник: Li Di

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Li DiBlood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral DrugsFocused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most… — @John Wiley&Sons Limited, @ @ @ @ Подробнее...
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