Электронная книга: Pedro Merino «Chemical Synthesis of Nucleoside Analogues»

Chemical Synthesis of Nucleoside Analogues

Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.

Издательство: "John Wiley&Sons Limited"

ISBN: 9781118498170

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Pedro Merino

Pedro Merino Criado (* 8. Juli 1987 in Manzanares) ist ein spanischer Straßenradrennfahrer.

Pedro Merino gewann 2005 in der Juniorenklasse eine Etappe bei der Vuelta al Besaya. In der Saison 2008 wurde er Zweiter beim Grand Prix Jean Masse und er gewann eine Etappe, sowie die Gesamtwertung beim Giro delle Valli Cuneesi nelle Alpi del Mare. Im nächsten Jahr wurde Merino von dem kanadischen Team TelTeck-H20 verpflichtet, welches jedoch aus finanziellen Gründen nie zu Stande kam. 2009 gewann er den Memorial Valenciaga und er wurde spanischer Meister im Straßenrennen der U23-Klasse. Ende des Jahres fuhr er für das ProTour-Team Fuji-Servetto als Stagiaire und er bekam dort einen Profivertrag für die Saison 2010.

Erfolge

2009
  • Spanien Spanischer Meister - Straßenrennen (U23)

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Источник: Pedro Merino

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Pedro MerinoChemical Synthesis of Nucleoside AnaloguesCompiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and… — @John Wiley&Sons Limited, @ @ @ @ Подробнее...
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