Электронная книга: Rolf Hilfiker «Polymorphism in the Pharmaceutical Industry. Solid Form and Drug Development»

Polymorphism in the Pharmaceutical Industry. Solid Form and Drug Development

Polymorphism in the Pharmaceutical Industry– Solid Form and Drug Development highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-stateproperties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemicalcompanies as well as for academics and newcomers to organic solid-state chemistry.

Издательство: "John Wiley&Sons Limited"

ISBN: 9783527697830

электронная книга

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Storey Richard A.Solid State Characterization of PharmaceuticalsThe field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum… — @John Wiley&Sons Limited, @ @ @ @ Подробнее...
19355.76электронная книга

См. также в других словарях:

  • Polymorphism (materials science) — Polymorphism in materials science is the ability of a solid material to exist in more than one form or crystal structure. Polymorphism can potentially be found in any crystalline material including polymers, minerals, and metals, and is related… …   Wikipedia

  • Cocrystal — The definition of a cocrystal has been debated in the crystallography field. The simplest definition of a cocrystal is a crystalline structure made up of two or more components in a definite stoichiometric ratio, where each component is defined… …   Wikipedia


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