Электронная книга: Binghe Wang «Evaluation of Drug Candidates for Preclinical Development. Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology»

Evaluation of Drug Candidates for Preclinical Development. Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the«right» drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspireforward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

Издательство: "John Wiley&Sons Limited"

ISBN: 9780470574881

электронная книга

Купить за 9884.31 руб и скачать на Litres

Другие книги автора:

КнигаОписаниеГодЦенаТип книги
Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease ApplicationsBrings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of… — John Wiley&Sons Limited, электронная книга Подробнее...19072.64электронная книга

Look at other dictionaries:

  • Central Drug Research Institute — The Central Drug Research Institute (CDRI) is one of the first laboratories to be established in India right after its independence. CDRI is among the thirty nine laboratories that are functioning under the aegis of the council of scientific and… …   Wikipedia