Электронная книга: Rankovic Zoran «Lead Generation Approaches in Drug Discovery»
|
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or«virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery. Издательство: "John Wiley&Sons Limited"
ISBN: 9780470584163 электронная книга Купить за 9521.78 руб и скачать на Litres |
Другие книги схожей тематики:
| Автор | Книга | Описание | Год | Цена | Тип книги |
|---|---|---|---|---|---|
| Benjamin Miller L. | Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science | Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated… — John Wiley&Sons Limited, электронная книга Подробнее... | 8034.98 | электронная книга |
См. также в других словарях:
Drug discovery — In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed. In the past most drugs have been discovered either by identifying the active ingredient from traditional… … Wikipedia
Natural product drug discovery — This article describes the utilization of natural resources in the process of finding new drug compounds, an approach commonly referred to as natural product drug discovery . Together with synthetic chemistry, they represent complementary… … Wikipedia
Discovery and development of HIV-protease inhibitors — Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed. In this prospective, the discovery of small molecule … Wikipedia
Discovery and development of small molecule c-Met inhibitors — The c Met (mesenchymal epithelial transition) tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and angiogenesis.[1] c Met is a receptor tyrosine kinase,[2] which can cause a wide variety of different cancers, such… … Wikipedia
Discovery and development of antiandrogens — In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important… … Wikipedia
drug — drug1 /drug/, n., v., drugged, drugging. n. 1. Pharm. a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well being. 2. (in federal law) a. any substance… … Universalium
