Электронная книга: Murad Ferid «Collaborative Innovation in Drug Discovery. Strategies for Public and Private Partnerships»

Collaborative Innovation in Drug Discovery. Strategies for Public and Private Partnerships

Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing patent expiration. Dr. Rathnam Chaguturu presents a case for collaboration between the pharmaceutical industry and academia that could reverse the industry's decline. Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships provides insight into the potential synergy of basing R&D in academia while leaving drug companies to turn hits into marketable products. As Founder and CEO of iDDPartners, focused on pharmaceutical innovation, Founding president of the International Chemical Biology Society, and Senior Director-Discovery Sciences, SRI International, Dr. Chaguturu has assembled a panel of experts from around the world to weigh in on issues that affect the two driving forces in medical advancement. Gain global perspectives on the benefits and potential issues surrounding collaborative innovation Discover how industries can come together to prevent another«Pharma Cliff» Learn how nonprofits are becoming the driving force behind innovation Read case studies of specific academia-pharma partnerships for real-life examples of successful collaboration Explore government initiatives that help foster cooperation between industry and academia Dr. Chaguturu’s thirty-five years of experience in academia and industry, managing new lead discovery projects and forging collaborative partnerships with academia, disease foundations, nonprofits, and government agencies lend him an informative perspective into the issues facing pharmaceutical progress. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships, he and his expert team provide insight into the various nuances of the debate.

Издательство: "John Wiley&Sons Limited"

ISBN: 9781118778159

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Murad, Ferid

born Sept. 14, 1936, Whiting, Ind., U.S.

U.S. pharmacologist.

He received his M.D. and Ph.D. from Western Reserve University (later Case Western Reserve University). Murad showed that nitroglycerin and related heart drugs induce the formation of nitric oxide, a gas that increases the diameter of blood vessels. Along with Robert F. Furchgott and Louis J. Ignarro, he was awarded a 1998 Nobel Prize for the discovery that nitric oxide acts as a signaling molecule in the cardiovascular system. Their combined work uncovered an entirely new mechanism for how blood vessels relax and widen. This discovery led to the development of the drug Viagra, which is used to treat erectile dysfunction.

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▪ American scientist
born Sept. 14, 1936, Whiting, Ind., U.S.

      American pharmacologist, who, along with Robert F. Furchgott (Furchgott, Robert F.) and Louis J. Ignarro (Ignarro, Louis J.), was co-awarded the 1998 Nobel Prize in Physiology or Medicine for the discovery that nitric oxide (NO) acts as a signaling molecule in the cardiovascular system. Their combined work uncovered an entirely new mechanism for how blood vessels (blood vessel) in the body relax and widen.

      Murad received his M.D. and Ph.D. from Western Reserve University (later Case Western Reserve University) in Cleveland, Ohio, in 1965. In addition to his clinical practice, Murad taught pharmacology at the University of Virginia School of Medicine, Charlottesville (1975–81), at Stanford University (1981–89), and then at Northwestern University (1988). While at Stanford he ventured into the private sector as a vice president of Abbott Laboratories (1988–92) and then became president of the Molecular Geriatrics Corporation (1993–95). He began teaching at the medical school of the University of Texas, Houston, in 1997.

      In 1977 Murad showed that nitroglycerin and several related heart drugs induce the formation of nitric oxide and that the colourless, odourless gas acts to increase the diameter of blood vessels in the body. Furchgott and Ignarro built on this work. About 1980 Furchgott demonstrated that cells in the endothelium, or inner lining, of blood vessels produce an unknown signaling molecule, which he named endothelium-derived relaxing factor (EDRF). This molecule signals smooth muscle cells in blood vessel walls to relax, dilating the vessels. Ignarro's research, conducted in 1986 and done independently of Furchgott's work, identified EDRF as nitric oxide. These discoveries led to the development of the anti-impotence drug sildenafil citrate (Viagra) and had the potential to unlock new approaches for understanding and treating other diseases.

      The Nobel Assembly of the Karolinska Institute in Stockholm, which presented the prize, said that the identification of a biological role for nitric oxide was surprising for several reasons. Nitric oxide was known mainly as a harmful air pollutant, released into the atmosphere from automobile engines and other combustion sources. In addition, it was a simple molecule, very different from the complex neurotransmitters and other signaling molecules that regulate many biological events. No other gas is known to act as a signaling molecule in the body.

      Murad was also the recipient of the Albert Lasker Basic Medical Research Award in 1996 for his discovery. Murad and Ignarro collaborated on Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications (1995).

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Источник: Murad, Ferid

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Murad FeridCollaborative Innovation in Drug Discovery. Strategies for Public and Private PartnershipsCan academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity… — John Wiley&Sons Limited, электронная книга Подробнее...
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