Электронная книга: Robert Meyers A. «Epigenetic Regulation and Epigenomics»

Epigenetic Regulation and Epigenomics

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The«epigenome» is a parallel to the word «genome,» and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care andpathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Издательство: "John Wiley&Sons Limited"

ISBN: 9783527668618

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См. также в других словарях:

  • Nutriepigenomics — is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non communicable diseases, such as… …   Wikipedia

  • Secreted frizzled-related protein 1 — The Secreted frizzled related protein (SFRP) family consists of five secreted glycoproteins in humans ( 300 amino acids in length) that act as extracellular signaling ligands. Each SFRP contains a cysteine rich domain (CRD) that shares 30 50%… …   Wikipedia

  • Epigenética — Este artículo o sección necesita referencias que aparezcan en una publicación acreditada, como revistas especializadas, monografías, prensa diaria o páginas de Internet fidedignas. Puedes añadirlas así o avisar al au …   Wikipedia Español

  • Methylated DNA immunoprecipitation — (MeDIP or mDIP) is a large scale (chromosome or genome wide) technique that is used to enrich for methylated DNA sequences. It consists of isolating methylated DNA fragments via an antibody raised against 5 methylcytosine (5mC). This technique… …   Wikipedia

  • Epigenetik — Die Epigenetik ist ein Spezialgebiet der Biologie. Sie befasst sich mit Zelleigenschaften (Phänotyp), die auf Tochterzellen vererbt werden und nicht in der DNA Sequenz (dem Genotyp) festgelegt sind. Hierbei erfolgen Veränderungen an den… …   Deutsch Wikipedia


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