Электронная книга: Kung-Jong Lui «Binary Data Analysis of Randomized Clinical Trials with Noncompliance»
|
It is quite common in a randomized clinical trial (RCT) to encounter patients who do not comply with their assigned treatment. Since noncompliance often occurs non-randomly, the commonly-used approaches, including both the as-treated (AT) and as-protocol (AP) analysis, and the intent-to-treat (ITT) (or as-randomized) analysis, are all well known to possibly produce a biased inference of the treatment efficacy. This book provides a systematic and organized approach to analyzing data for RCTs with noncompliance under the most frequently-encountered situations. These include parallel sampling, stratified sampling, cluster sampling, parallel sampling with subsequent missing outcomes, and a series of dependent Bernoulli sampling for repeated measurements. The author provides a comprehensive approach by using contingency tables to illustrate the latent probability structure of observed data. Using real-life examples, computer-simulated data and exercises in each chapter, the book illustrates the underlying theory in an accessible, and easy to understand way. Key features: Consort-flow diagrams and numerical examples are used to illustrate the bias of commonly used approaches, such as, AT analysis, AP analysis and ITT analysis for a RCT with noncompliance. Real-life examples are used throughout the book to explain the practical usefulness of test procedures and estimators. Each chapter is self-contained, allowing the book to be used as a reference source. Includes SAS programs which can be easily modified in calculating the required sample size. Biostatisticians, clinicians, researchers and data analysts working in pharmaceutical industries will benefit from this book. This text can also be used as supplemental material for a course focusing on clinical statistics or experimental trials in epidemiology, psychology and sociology. Издательство: "John Wiley&Sons Limited"
ISBN: 9781119991601 электронная книга Купить за 9443.74 руб и скачать на Litres |
Другие книги автора:
| Книга | Описание | Год | Цена | Тип книги |
|---|---|---|---|---|
| Crossover Designs. Testing, Estimation, and Sample Size | A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by… — John Wiley&Sons Limited, электронная книга Подробнее... | электронная книга |
См. также в других словарях:
Jow-Ga Kung Fu — Part of the series on Chinese martial arts List of Chinese martial arts Terms Kung fu (功夫) Wushu (武術) Qigong (氣功) Historical places … Wikipedia
Cai Li Fo — Choy Li Fut redirects here. For the Hong Kong film, see Choy Lee Fut (film). Cai Li Fo Chinese 蔡李佛 Transcriptions … Wikipedia
Wing chun — Pour les articles homonymes, voir Wing Chun (homonymie). Wing chun (詠春) … Wikipédia en Français
Hyeong — Tul redirects here. For other meanings, see TUL (disambiguation). Hyeong Hangul 형, 품세 (pre 1987) 품새 (post 1987), 틀 Hanja 形, 品勢(품세), no Hanja for 품새 … Wikipedia
Ken-ichi le disciple ultime — Shijō Saikyō no Deshi Kenichi 史上最強の弟子ケンイチ Genre arts martiaux, comédie, romance Manga Type Shōnen Auteurs Shun Matsuena (scénario) Shun Matsuena (dessin) … Wikipédia en Français
List of Singapore-related topics — This is a list of topics related to Singapore. For a similar list in alphabetical order, see list of Singapore related topics by alphabetical order. Those interested in the subject can monitor changes to the pages by clicking on Related changes… … Wikipedia
