Книга: Shakir Saleem,Jahangir Alam and Imran Kazmi «Synthesis and antimicrobial activity of Phthalimide derivatives»
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Производитель: "LAP Lambert Academic Publishing" A series of novel phthalimide derivatives (SV 1-8) have been synthesized and evaluated for antimicrobial activity. The target compounds were prepared by fusion of glycine with phthalic anhydride at 150-155 ?C to afford 2-(1, 3- dioxoisoindolin-2-yl) acetic acid. The compound 2-(1, 3-dioxoisoindolin-2-yl) acetic acid was treated with thionyl chloride in chloroform to afford 2-(1, 3-dioxoisoindolin-2-yl) acetyl chloride which was further treated with substituted phenols in presence of anhydrous potassium carbonate in dry acetone yielded the final compounds (SV1-8). The structures of the target compounds were characterized on the basis of their m. p., TLC, IR and 1H-NMR data. All the target compounds were evaluated for antibacterial and antifungal activity. ISBN:9783845418384 Издательство: "LAP Lambert Academic Publishing" (2012)
ISBN: 9783845418384 |
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