Книга: Haresh Chaudhary,B.N. Patel and D.M. Patel «Simvastatin Solid Dispersion Prepared By Microwave Fusion Technique»

Производитель: "LAP Lambert Academic Publishing"

Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0. 76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0. 76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion. ISBN:9783846504055

Издательство: "LAP Lambert Academic Publishing" (2014)

ISBN: 9783846504055