Книга: L. Kalyani and A. Lakshmana Rao «RP-HPLC Method for the Determination of Sertraline»

RP-HPLC Method for the Determination of Sertraline

Производитель: "LAP Lambert Academic Publishing"

A simple, accurate and precise RP-HPLC method has been developed and validated for the determination of Sertraline in bulk and tablet dosage forms. Separation of the drug was achieved on a Symmetry C18 column (150mm x 4. 6mm, 5 m) using a mobile phase consisting of ammonium acetate buffer and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0. 8ml/min at ambient temperature. The quantification was achieved with UV detection at 273nm. The linearity was observed over the concentration range of 50-250 g/ml with a correlation coefficient of 0. 999. The accuracy of the proposed method was determined by recovery studies and found to be 98-100. 3% of Sertraline. The proposed method can be employed for routine quality control analysis of Sertraline in tablet dosage forms. ISBN:9783659587207

Издательство: "LAP Lambert Academic Publishing" (2014)

ISBN: 9783659587207

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