Книга: Shashidher Burra and Veera Reddy Prabakhar Reddy «Formulation And Evaluation Of Carvedilol Liquisolid Tablets»

Производитель: "LAP Lambert Academic Publishing"

The present study enlightens to enhance the dissolution profile, absorption efficiency and bioavailability of water insoluble drugs like carvedilol. A novel Powder Solution Technology involves absorption and adsorption efficiency, which makes use of liquid medications admixed with suitable carriers and coating materials and formulated into a free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material ratio from 20:1 to 5:1. Di calcium phosphate, Avicel PH 200 were showing acceptable flow properties compared with Avicel PH 101 and Lactose. Higher dissolution rates (98. 4%) were observed in Poly ethylene glycol 400 and Avicel PH 200 containing liquisolid formulations (F5) compared with marketed product (CARCA 12. 5 mg tablets) 81% drug release. Poly ethylene glycol 400 was... ISBN:9783659183140

Издательство: "LAP Lambert Academic Publishing" (2012)

ISBN: 9783659183140