Книга: Ravi B. Patel,R. Badmanaban and J. B. Dave «Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form»

Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form

Производитель: "LAP Lambert Academic Publishing"

A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 g/mL and 10-60 g/mL with R2 of 0. 9998 and 0. 9989 for CEF&TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0. 9993 and 0. 9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF&TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation.... ISBN:9783659425288

Издательство: "LAP Lambert Academic Publishing" (2013)

ISBN: 9783659425288

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