Книга: Ajaz Ahmad Waza and Mahboob Ul Hussain «Cloning, Expression and Purification of kir6. 1 in Bacterial system»

Производитель: "LAP Lambert Academic Publishing"

Adenosine-triphosphate-sensitive K+channels K+(ATP) are the protein channels responsive to changes in ATP/adenosine diphosphate (ADP) ratio and provide a means to couple movement of potassium ions, to relate membrane potential with cellular energy status. Various subfamilies of K+(ATP) channel proteins, designated as Kir1. 0 to 7. 0, share significant amino-acid homology (40%) among them. The Kir6. 0 subfamily consists of Kir6. 1 and Kir6. 2 proteins with around 70% amino acid homology. Kir6. 1 is widely expressed in tissues, including pancreatic islets, heart, skeletal muscle and brain. K+(ATP) channels are assembled from two different subunits, a Kir subunit that forms the ion-conducting pore and a sulfonylurea receptor (SUR), a member of the ABCC subfamily. Activation of an K+(ATP) channel is known to be an important part of endogenous protective signalling that promotes cellular survival under conditions of metabolic stress. More recently, evidences suggest that activation of... ISBN:9783659457029

Издательство: "LAP Lambert Academic Publishing" (2013)

ISBN: 9783659457029