Книга: Ritabrata Banerjee «Analysis of genetic and epigenetic alterations in breast carcinomas»
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Производитель: "LAP Lambert Academic Publishing" Cancer is a group of diseases in which cells in the body grow, change and multiply out of control. Usually, cancer is named after the body part in which it originated; thus, breast cancer refers to the erratic growth and proliferation of cells that originate in the breast tissue. Breast cancer is a complex, multifactorial disease where there is a strong interplay between genetic and environmental factors. Comparative genomic hybridization studies on primary BC and BC cell lines describe a complex pattern of DNA gains and losses in the tumor compared with normal tissue. Among these deleted regions we have focused on chr. 11q24. 2 region To understand the importance of frequent deletions at chromosome 11q24. 2 region in breast carcinoma, alterations (deletion/methylation) of the candidate genes PIG8 and CHEK1 located in this region were analyzed in breast carcinoma samples. Among these genes, PIG8 (35%), CHEK1 (31%). Comparable frequency of promoter methylation (26-35%) was observed for... ISBN:9783659159336 Издательство: "LAP Lambert Academic Publishing" (2012)
ISBN: 9783659159336 |
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