Книга: Gagan Sharma and Ravi Sharma «Analytical Method Development and Validation»
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Производитель: "LAP Lambert Academic Publishing" A simple reverse phase liquid Chromatographic method has been developed and subsequently validated for simultaneous determination of Pioglitazone and Glimepiride in combination. The separation was carried out using a mobile phase of phosphate buffer (pH-4. 5): Acetonitrile (45:55) v/v and using methanol as diluent. The column used was Inertsil ODS (250 mm x 4. 6 mm i. d., 5?m) with flow rate of 1 ml/min using UV detection at 225 nm. The described method was linear over a concentration range of 5-50?g/ml and 5-25 ?g/ml for the assay of Pioglitazone and Glimepiride respectively. The retention times of Pioglitazone and Glimepiride were found to be4. 6 and 7. 7min respectively. Results of analysis were validated statistically and by recovery studies. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Pioglitazone and Glimepiride bulk drug and in its pharmaceutical dosage form. ISBN:9783659253997 Издательство: "LAP Lambert Academic Publishing" (2012)
ISBN: 9783659253997 |
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