Книга: HAMPTON, BRENDA «SLICK (изд. 2015 г. )»
Производитель: "Неизвестный" Lifelong friends Dana and Sylvia often share their dirty little secrets, but Sylvia isn`t happy about having to cover up Dana`s ongoing affair with Lewis. Sylvia despises the man her friend is creeping with. In addition to sexing Dana, Lewis believes that he can have any woman he wants wrapped around his finger. That includes Sylvia, but after several sexual advances from Lewis, she makes it clear that only one man has her heart. She`s head over heels for her handsome, no-nonsense boss, Jonathan Taylor. Jonathan is somewhat clueless about what is transpiring behind closed doors. He suspects that his wife, Dana, has some skeletons in her closet, but when the truth is revealed about Dana`s adulterous ways, he`s prepared to take action. Jonathan`s retaliation will leave his wife`s head spinning in circles, and her best friend sexually satisfied. ISBN:9781622867141 Издательство: "Неизвестный" (2015)
ISBN: 9781622867141 |
Hampton
I. biographical name Wade 1751?-1835 American general II. biographical name Wade 1818-1902 grandson of preceding American politician & Confederate general III. geographical name city & port SE Virginia E of Newport News on Hampton Roads population 146,437
Источник: Hampton
BRENDA
BRENDA is the comprehensive
* Large increase in updating speed
* Development of new EC-tree browser
* Taxonomy-tree browser
* Chemical substructure search engine for ligand structure
* Development of controlled vocabulary
* Ontology for some information fields
* Thesaurus for ligand names.
Usage
The database covers 40 data fields with information about nomenclature, reaction and specificity, enzyme structure,
The resource is available free of charge for academic, non-profit users; commercial use requires a license. For use it requires registration by email. The database can be searched by EC number, enzyme name, organism, or an advanced search combining these terms.
Example
As an example you can use the quick search to search for pyruvate dehydrogenase. This search gives several forms of the enzyme. If you click on pyruvate dehydrogenase (NADP+) it takes you to a page it gives you information on:
* Enzyme nomenclature
* Enzyme ligand interactions
* Functional parameters
* Organism related information
* Enzyme structure
* Molecular properties
* Bibliography/links/Disease
This page also shows all the
This query gives the result pyruvate dehydrogenase (lipoamide).
Other methods of searching include full text search, substructure search, TaxTree search (search an organism in taxonomy tree), search the EC tree and it is possible to do a sequence search.
Other databases
BRENDA also links to other databases. Including KEGG which provides information about the pathway that the enzyme is involved in. It also links to gene ontology information through the GO website. There is also links to the literature through PubMed. Other databases that BRENDA link to include:
* ExPASy
* NCBI databases (Protein, nucleotide, structure, genome, OMIM, Domains
* IUBMB enzyme nomenclature
* PDB database (3D information)
* PROSITE
* SYSTERS
* Protein mutant database
* SCOP
* CATH
* InterPro
Database extensions
As of January 2007, the data repository was complemented by text-mining data inBarthelmes J, Ebeling C, Chang A, Schomburg I, Schomburg D (2007). BRENDA, AMENDA and FRENDA: the enzyme information system in 2007. "Nucleic Acids Res, 35(Database issue):D511-4".] : References * Schomburg I, Hofmann O, Bänsch C, Chang A, Schomburg D (2000). Enzyme data and metabolic information: BRENDA, a resource for research in biology, biochemistry, and medicine. "Gene Funct Dis, 3-4:109-18". External links * [http://www.brenda-enzymes.info Official BRENDA website] Источник: BRENDA
* AMENDA (Automatic Mining of ENzyme DAta); and
* FRENDA (Full Reference ENzyme DAta)
* Schomburg D, Schomburg I (2001). Springer Handbook of Enzymes, 2nd Ed. Springer, Heidelberg.
* Schomburg I, Chang A, Schomburg D (2002). BRENDA, enzyme data and metabolic information. "Nucleic Acids Res, 30:47-9".
* Schomburg I, Chang A, Hofmann O, Ebeling C, Ehrentreich F, Schomburg D (2002). BRENDA: a resource for enzyme data and metabolic information. "Trends Biochem Sci, 27(1):54-6".
* Pharkya P, Nikolaev EV, Maranas CD (2003). Review of the BRENDA Database. "Metab Eng, 5(2):71-3".
* Schomburg I, Chang A, Ebeling C, Gremse M, Heldt C, Huhn G, Schomburg D (2004). BRENDA, the enzyme database: updates and major new developments. "Nucleic Acids Res, 32(Database issue):D431-3".
* [http://www.empproject.com/ EMP: Enzymes and Metabolic Pathways database]
* [http://www.worthington-biochem.com/default.html Worthington Biochemical Corporation Enzyme Manual]
* [http://www.chem.qmul.ac.uk/iubmb/enzyme/ Enzyme Nomenclature]
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