Книга: Rachna Mishra «Synthesis of an Ammended Analogue of Delavirdine»

Synthesis of an Ammended Analogue of Delavirdine

Производитель: "LAP Lambert Academic Publishing"

The efficacy of delavirdine is lower than other FDA approved NNRTIs, therefore, the US department of health and Human Services has recommended its use not as a part of initial therapy but in combination with other drugs. To circumvent this therapeutic difficulty of delavirdine, we amended its structure to develop a novel analogue by replacing its less active indole fragment with a more active anti-HIV prone isatin s Mannich bases. The molecular assemblage of delavirdine was concurrently also altered by rearranging its vital fragments to allow it to emerge with altogether a different molecular setting. ISBN:9783659635229

Издательство: "LAP Lambert Academic Publishing" (2014)

ISBN: 9783659635229

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