Книга: Suresh Jain «Multicomponent analysis using UV-visible spectrophotometer»
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Производитель: "LAP Lambert Academic Publishing" In the present work, a simple, cost effective, reproducible and reliable method for simultaneous estimation of Glimepiride and Pioglitazone-HCl in bulk and marketed formulation using simultaneous equation was developed and validated. The developed method involved measurement of absorbances at wavelength of 228 nm and 265. 5 nm ( absorption maxima of Glimepiride and Pioglitazone-HCl respectively), which these obeyed the principle of simultaneous equation method. Both the drugs obeyed Beer-Lambert s law in concentration ranges (For Glimepiride 4-20 and for Pioglitazone-HCl 10-50 mcg/ml). The validation parameters studied according to I. C. H Q2B guidelines. The recovery studies (found to be 100. 3 % and 100. 01 % respectively). The molar absorptivity and Sandell s sensitivity values show the sensitivity of the method. The values of coefficient of variance suggest high level of precision of the method. The LOD and LOQ value for Glimepiride were 0. 0161 and 0. 0486 mcg/ml and of Pioglitazone-HCl... ISBN:9783659563287 Издательство: "LAP Lambert Academic Publishing" (2014)
ISBN: 9783659563287 |
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Chemometrics — is the science of extracting information from chemical systems by data driven means. It is a highly interfacial discipline, using methods frequently employed in core data analytic disciplines such as multivariate statistics, applied mathematics,… … Wikipedia
