Книга: Ragwa Farid Mansour,Mohamed Ahmed Etman and Abd-Elazim Rafaat Ebian «Gelrite-Based In situ Gel for the Nasal Delivery»

Производитель: "LAP Lambert Academic Publishing"

Salbutamol sulfate (SS), a direct acting sympathomimetic; used for the treatment of acute and chronic asthma, was formulated as gelerite in-situ gels. SS in-situ gels (2% w/w) were prepared at concentration of gellan gum 0. 2%, 0. 4% and 0. 8% w/v with methyl paraben (0. 05%) as preservative. In-vitro release in simulated nasal fluid showed relatively fast release and release kinetics followed diffusion kinetic model. In-vivo mucoadhesiveness test performed in rats, showed prolonged mucociliary transport time from 5 min (control solution) to 16. 5 and 19. 5 minutes for formulations containing 0. 4%&0. 8% respectively. In-situ gels have demonstrated an adequate safety to the nasal mucosa of rats. The 0. 4 % in-situ gel remained liquid for 6 months without occurrence of turbidity or gelation at storage temperature conditions. Statistical analysis revealed non-significant difference in content uniformity or release compared to the fresh ones. In-situ gel is a promising approach for the... ISBN:9783659639692

Издательство: "LAP Lambert Academic Publishing" (2014)

ISBN: 9783659639692