Книга: S.Hasan Amrohi,Afra Nazneen and Anas Rasheed «RP-HPLC method for the determination of Anti-Anginal Drugs»

RP-HPLC method for the determination of Anti-Anginal Drugs

Производитель: "LAP Lambert Academic Publishing"

A simple, specific, accurate and precise stability indicating reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous estimation of Aspirin and Isosorbide 5-mononitrate in bulk drug and its pharmaceutical dosage form. A chromatographic separation was achieved with reverse phase phenomenex Luna 5 C18 (2) 100A (250 ? 4. 60 mm) column in an isocratic mode at ambient temperature. The mobile phase consisting of water: methanol: acetonitrile (55:28:17% v/v/v) at a flow rate of 1 ml/min. The eluents were monitored at 217 nm. The retention times of Aspirin and Isosorbide 5-mononitrate were found to be 2. 05 0. 056 min and 4. 27 0. 016 min respectively. The regression analysis revealed linearity in the concentration range of 1-10 g/ml and 1-10 g/ml for Aspirin and Isosorbide 5-mononitrate respectively. The method was validated in terms of linearity, accuracy, precision, limit of detection (LOD), limit of quantification (LOQ) in accordance... ISBN:9783659359651

Издательство: "LAP Lambert Academic Publishing" (2013)

ISBN: 9783659359651

Поделиться ссылкой на выделенное

Прямая ссылка:
Нажмите правой клавишей мыши и выберите «Копировать ссылку»