Книга: Jannek Hauser «Regulation of B cell Development by Antigen Receptors»
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Производитель: "LAP Lambert Academic Publishing" The E-protein E2A is well known for its many roles during B cell development. Antigen receptor signaling that leads to inhibition of E2A by the calcium-sensor protein calmodulin (CaM) has therefore very broad implications. The down- regulation of the surrogate light chains of the pre-B cell receptor and also the co-receptor CD19 was shown to be through CaM inhibition of E2A. Furthermore, several components of the Ig recombination machinery including RAG1 and RAG2 are down-regulated by this mechanism, and the recombination complex was shown to include the RAGs, Pax5 and E2A, which can be directly released from the Ig heavy chain locus by pre-B cell receptor signaling through CaM to achieve allelic exclusion. The tight regulation of the antibody diversification enzyme AID is also dependent on CaM inhibition of E2A, and a negative feedback regulation of the pre-B and B cell receptor proteins and co-receptors and proteins in signal pathways from the receptor was also... ISBN:9783844325010 Издательство: "LAP Lambert Academic Publishing" (2011)
ISBN: 9783844325010 |
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