Книга: Dhirendra C. Patel and Jitendra S. Patel «Poloxamer»
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Производитель: "LAP Lambert Academic Publishing" Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. Now a day, Poloxamer are widely used in different drug delivery systems due to its biodegradability, high solubility and low toxicity. Poloxamers contain both hydrophilic and hydrophobic part, so they are used widely as surfactant and emulsifier in the formulation. Poloxamer are used in solid dispersion as solubility enhancer. Pluronic grade has thermo reversible gelation property, liquid at room temperature and convert gel at body temperature, so it is used in the control release formulation. Poloxamer are used for improve the stability of Nanoparticle and liposome. Poloxamers are used in solid suppositories for improve the dissolution of poorly soluble drugs and decrease the rectal irritation compare to conventional polymer like polyethylene glycol. Poloxamer are also used in the biological preparation as stabilizer. ISBN:9783659304262 Издательство: "LAP Lambert Academic Publishing" (2012)
ISBN: 9783659304262 |
См. также в других словарях:
Poloxamer — Poloxamers, also known by the trade name Pluronics [http://worldaccount.basf.com/wa/NAFTA en US/Catalog/ChemicalsNAFTA/pi/BASF/Brand/pluronic] , are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene… … Wikipedia
Poloxamer — Poloxamere sind Blockcopolymere aus Ethylenoxid und Propylenoxid. Es handelt sich um schaumarme und schaumdämpfende nichtionische Tenside, die zur Dispergierung und Emulgierung in der chemisch technischen Industrie Anwendung finden. Der… … Deutsch Wikipedia
Poloxamer 407 — is a hydrophilic non ionic surfactant of the more general class of copolymers known as poloxamers. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of… … Wikipedia
poloxamer 182L — a liquid poloxamer, having an average molecular weight of 2450; used as a food additive and pharmaceutic aid … Medical dictionary
poloxamer 188 — a waxy poloxamer, having an average molecular weight of 8350; used as a cathartic, administered orally. Called also poloxalkol … Medical dictionary
poloxamer 331 — a liquid poloxamer, having an average molecular weight of 3800; used as a food additive … Medical dictionary
