Книга: Sebastian Stolzenberg «Molecular Mechanisms in the Function of Neurotransmitter Transporters»
|
Производитель: "LAP Lambert Academic Publishing" In my Ph. D. research work, I investigate functional mechanisms of complex molecular machines in the cell membrane that carry out the transport (reuptake) of neurotransmitter molecules into the cell. I apply and develop methods of computational biophysics to reveal and quantify the molecular transport process that is essential for the ability of the cell to continue to signal. Such detailed understanding is highly significant because dysfunction of these transporter proteins is known to be involved in neurodegenerative diseases, depression, epilepsy and stroke. The molecular mechanistic insights gained on multiple scales from my research work pertain to (1) a major conformational transition in the substrate translocation mechanism of Glutamate Transporters, and (2) allosteric changes in the substrate transport mechanism of the Neurotransmitter:Sodium Symporter proteins. The computational approaches that enabled these mechanistic insights include Motion Planning, mixed Elastic Network... ISBN:9783659562921 Издательство: "LAP Lambert Academic Publishing" (2014)
ISBN: 9783659562921 |
См. также в других словарях:
Mechanisms of schizophrenia — The underlying mechanisms of schizophrenia, a mental disorder characterized by a disintegration of the processes of thinking and of emotional responsiveness, are complex. There are a number of theories which attempt to explain the link between… … Wikipedia
Neurobiology — is the study of cells of the nervous system and the organization of these cells into functional circuits that process information and mediate behavior. [Shepard, G. M. (1994). Neurobiology. 3rd Ed. Oxford University Press. ISBN 0 19 508843 3] It… … Wikipedia
Norepinephrine transporter — Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Identifiers Symbols SLC6A2; NAT1; NET; NET1; SLC6A5 External IDs … Wikipedia
Dopamine transporter — Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Identifiers Symbols … Wikipedia
Blut-Gehirn-Schranke — Die Blut Hirn Schranke, auch Blut Gehirn Schranke genannt, ist eine bei allen Landwirbeltieren (Tetrapoda) im Gehirn vorhandene physiologische Barriere zwischen dem Blutkreislauf und dem Zentralnervensystem. Sie dient dazu, die Milieubedingungen… … Deutsch Wikipedia
Endotheliale Blut-Hirn-Schranke — Die Blut Hirn Schranke, auch Blut Gehirn Schranke genannt, ist eine bei allen Landwirbeltieren (Tetrapoda) im Gehirn vorhandene physiologische Barriere zwischen dem Blutkreislauf und dem Zentralnervensystem. Sie dient dazu, die Milieubedingungen… … Deutsch Wikipedia
