Книга: Kanny Diallo «Macrophages innate immune responses to bacterial infections»
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Производитель: "LAP Lambert Academic Publishing" Macrophages are the first line of defense against microbial pathogens; they recognize microbial structures and products via surface receptors and intracellular antigen sensors. Engagement of surface receptors results in phagocytosis of the microbe into a specialized vacuole, the phagosome. Through a series of fusogenic events, the phagosome matures into a microbicidal phagolysosome that is highly acidic and contains a number of degradative enzymes and toxic molecules that cause destruction of the microbe. Salmonella typhimurium (S. typhimurium) and Legionella pneumophila (L. pneumophila) are two pathogenic Gram-negative bacteria that are able to block phagosome maturation. The hypothesis is that the macrophages response to these pathogens contains a common as well as a pathogen-specific response. Genome-wide transcription profiling approach was used to compare macrophage responses to phagocytosis of S. typhimurium or L. pneumophila at early time points, 2h and 4h post-infection. This... ISBN:9783659289255 Издательство: "LAP Lambert Academic Publishing" (2012)
ISBN: 9783659289255 |
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