Книга: Sachinkumar Patil,Shitalkumar Patil and Amit Jagdale «Formulation and Evaluation of an In Situ Gel for Ocular Delivery»

Производитель: "LAP Lambert Academic Publishing"

Norfloxacin ophthalmic solution has been shown to be effective ocular infections and may be used in patients with chronic conjunctivitis or ocular irritation. Norfloxacin in-situ gel was prepared using various concentrations of polymers such as Carbopol-940 (0., 0. 2, 0. 3 0. 4and 0. 5% w/v), HPMC- E50LV (1. 5 % w/v), HPMC E4M (0. 6 %w/v) and HPMC K4M (0. 5% w/v) by pH triggered gelling system with an objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy of drug. The prepared in-situ gels were then evaluated for their visual appearance, clarity, pH, drug content analysis, in-vitro gelation (Gelling capacity), rheological studies, sterility testing, textureanalysis and in-vitro drug release studies. It is evident from these studies that, formed polymeric in-situ gels had transparent, clear possessing satisfactory gelling capacity. The... ISBN:9783659461910

Издательство: "LAP Lambert Academic Publishing" (2013)

ISBN: 9783659461910