Книга: Udhumansha Ubaidulla and Vijaya Kumar M.P. «Enhancement of Solubility&Dissolution Rate by Co-Crystal Technology»
|
Производитель: "LAP Lambert Academic Publishing" Acyclovir conventional tablets have been used for long period for the treatment of viral infections. When orally administered, it is showing slow and incomplete absorption from gastrointestinal tract. The total oral bioavailability of acyclovir is between 15 30% due to poorly soluble drug and short plasma half life (3 Hrs). Oral bioavailability of acyclovir can be achieved by improving the solubility and dissolution rate. Several techniques have been used to improve the solubility and dissolution rate of acyclovir such as solid dispersions and spherical agglomerates and complexes. Co- crystals recently been used for improving oral solubility and dissolution rate of the drugs. The present investigation of the work is to prepare acyclovir co-crystals with chitosan by using solvent change method to improve the solubility and dissolution rate of acyclovir. The second objective of this work is to extent the maximum bioavailability of acyclovir by retaining the drug in gastric region for... ISBN:9783659379796 Издательство: "LAP Lambert Academic Publishing" (2013)
ISBN: 9783659379796 |
См. также в других словарях:
materials science — the study of the characteristics and uses of various materials, as glass, plastics, and metals. [1960 65] * * * Study of the properties of solid materials and how those properties are determined by the material s composition and structure, both… … Universalium
Caesium chloride — Caesium chloride … Wikipedia
Cocrystal — The definition of a cocrystal has been debated in the crystallography field. The simplest definition of a cocrystal is a crystalline structure made up of two or more components in a definite stoichiometric ratio, where each component is defined… … Wikipedia
Hydrogen peroxide — IUPAC name … Wikipedia
