Книга: Shemsia Mohamed Hudie and Ghirma Moges «Determination of the Antiretroviral Drug Lamivudine»

Determination of the Antiretroviral Drug Lamivudine

Производитель: "LAP Lambert Academic Publishing"

A solid-state iodide selective electrode with Ag2S-AgI adsorbed on graphite rod, recovered from a dry cell, was prepared and validated for its typical response characteristics with an objective to develop a potentiometric titration system for rapid measurements of Lamuvidine (LMV) in tablets used as an antiretroviral drug for Hepatis B and HIV patients. The partial validationexhibited typical response values of linear range of 10-6 to 10-1 M iodide and a slope 57. 57 mV/decade which reasonably agreed with early data from our Laboratory. The basis of LMV determination is its oxidation by excess bromine generated from bromate-bromide mixture. The unreacted bromine oxidized the added excess iodide to iodine. The amount of bromine consumed by LMV, the basis of its determination, was determined by subtracting the back-titrated iodine with thiosulphate whose end-point was located potentiometrically with the solid state iodide selective electrode against a reference electrode. The... ISBN:9783846528778

Издательство: "LAP Lambert Academic Publishing" (2011)

ISBN: 9783846528778

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