Книга: Rita Turnaturi and Lorella Pasquinucci «Multitarget opioid ligands as suitable candidates for pain management»

Производитель: "LAP Lambert Academic Publishing"

For the clinical management of acute and chronic pain, a possible therapeutic approach is the association between two or more drugs, which produce their biological effects on two or more different sites of action, in order to modulate directly or indirectly profile analgesic and adverse effects. Given the advantages of polypharmacology, in the drug discovery process has been established the strategy `one-molecule multiple targets`. Considering that the various mediators involved in the circuit of pain represent potential targets for different pharmacological interventions, opioid-opioid or non-opioid-opioid multitarget ligands are potential drug candidates for the management of pain conditions. Multitarget ligands, able to act simultaneously on multiple opioid receptors subtypes, showed low propensity to induce side effects. Three chapters constitute this contribution; the first is focused on pain mechanisms and mediators and examine the main drugs clinically used. The second chapter... ISBN:9783659562266

Издательство: "LAP Lambert Academic Publishing" (2014)

ISBN: 9783659562266