Книга: Csaba Szigeti,Peter Santha and Gabor Jancso «Capsaicin and Pain»
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Производитель: "LAP Lambert Academic Publishing" Different types of mechanical, chemical and metabolic injuries may damage peripheral nerves and produce impairments in sensory, motor and autonomic functions. Transection of peripheral nerves results in neurotmesis, the most severe form of nerve injury characterized by a complete division of the nerve, which may be associated with neuropathic pain and related painful dysaesthesias. It was suggested that both the axotomy- and the perineural capsaicin treatment-induced reductions in the sensitivity of primary afferent neurons to capsaicin might be related to a downregulation of the capsaicin/TRPV1 receptor. Changes in TRPV1 protein/mRNA level were investigated with in situ hybridization, quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot analysis. Our results suggest the involvement of distinct cellular mechanisms in the regulation of the TRPV1 mRNA expression of damaged neurons, specifically triggered by the nature of the injury. The... ISBN:9783659402449 Издательство: "LAP Lambert Academic Publishing" (2013)
ISBN: 9783659402449 |
См. также в других словарях:
Capsaicin — Chembox new ImageFile1 = Capsaicin chemical structure.png ImageSize1 = 250px ImageFile2 = Capsaicin 3D vdW.png ImageSize2 = 250px IUPACName = 8 Methyl N vanillyl trans 6 nonenamide OtherNames = (E) N (4 Hydroxy 3 methoxybenzyl) 8 methylnon 6… … Wikipedia
Pain, shingles — Localized pain in the area of involvement of shingles. When such pain persists beyond one month it is referred to as postherpetic neuralgia.The most common complication of shingles is postherpetic neuralgia. This occurs when the pain associated… … Medical dictionary
capsaicin — A component of certain plants, including cayenne and red pepper, used topically for peripheral nerve pain. It is also being studied for controlling mucositis pain after chemotherapy and radiation therapy … English dictionary of cancer terms
capsaicin — Alkaloidal principle in the fruits of various species of Capsicum, with the same uses as capsicum. It depletes substance P from sensory nerve endings; Sometimes used for pain in postherpetic neuralgia. * * * cap·sa·icin kap sā ə sən n a colorless … Medical dictionary
Discovery and development of TRPV1 antagonists — Chronic pain remains a recognized unmet medical need. Consequently, the search for new analgesic agents is being intensively studied by the pharmaceutical industry. The TRPV1 receptor is an ion channel that has been implicated in mediation of… … Wikipedia
Neuropathic pain — results from lesions or diseases affecting the somatosensory system.[1] It may be associated with abnormal sensations called dysesthesia, which occur spontaneously and allodynia that occurs in response to external stimuli. Neuropathic pain may… … Wikipedia
